Bone loss caused by iron overload in a murine model: importance of oxidative stress.

abstract：:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the most effective tumor immunotherapy available. Although allo-HSCT provides beneficial graft-versus-tumor effects, acute GVHD (aGVHD) is the primary source of morbidity and mortality after HSCT. Diagnosis of aGVHD is typically based on clinical sympto...

journal_title：Blood

authors： Paczesny S

更新日期：2013-01-24 00:00:00

abstract：:During mouse cytomegalovirus (CMV) infection, a population of Ly49H(+) natural killer (NK) cells expands and is responsible for disease clearance through the induction of a "memory NK-cell response." Whether similar events occur in human CMV infection is unknown. In the present study, we characterized the kinetics of ...

journal_title：Blood

authors： Foley B,Cooley S,Verneris MR,Pitt M,Curtsinger J,Luo X,Lopez-Vergès S,Lanier LL,Weisdorf D,Miller JS

更新日期：2012-03-15 00:00:00

abstract：:Affinity purified anticardiolipin antibodies (ACLA) raised in rabbits showed cross-reactivities with various negatively charged phospholipids as shown by both the solid phase enzyme-linked immunosorbent assay (ELISA) and inhibition studies. In ELISA, ACLA showed strong cross-reactivity to both sphingomyelin (SM) and p...

journal_title：Blood

authors： Lin YL,Wang CT

更新日期：1992-12-15 00:00:00

abstract：:The von Willebrand factor propeptide, vW AgII, has been shown to be required for the formation of vWF multimers and sorting of vWF to storage granules; whether these 2 processes are independent events has been unclear. Chimeric constructs of human and canine vWF were developed to further define these processes and to ...

journal_title：Blood

authors： Haberichter SL,Fahs SA,Montgomery RR

更新日期：2000-09-01 00:00:00

abstract：:The intercellular crosstalk between hematological malignancies and the tumor microenvironment is mediated by cell-to-cell interactions and soluble factors. One component of the secretome that is gaining increasing attention is the extracellular vesicles and, in particular, the exosomes. Apart from the role as vectors ...

journal_title：Blood

authors： Vardaki I,Sanchez C,Fonseca P,Olsson M,Chioureas D,Rassidakis G,Ullén A,Zhivotovsky B,Björkholm M,Panaretakis T

更新日期：2016-12-08 00:00:00

abstract：:Endothelial cells synthesize a heterodimeric adhesion molecule, the vitronectin receptor (VnR), which is similar to the platelet glycoprotein (GP)IIb/IIIa complex. The subunits of the endothelial VnR (VnR alpha and GPIIIa) have been studied for their ability to express alloantigens associated with platelet GPIIb and I...

journal_title：Blood

authors： Giltay JC,Leeksma OC,von dem Borne AE,van Mourik JA

更新日期：1988-07-01 00:00:00

abstract：:Macrophages infiltrating solid tumors exhibit a tumor-supporting phenotype and are critical for tumor development. Little is known which tumor-derived signal provokes this phenotype shift and how these signals are interpreted in macrophages to support tumor growth. We used the supernatant of apoptotic cells and notice...

journal_title：Blood

authors： Herr B,Zhou J,Werno C,Menrad H,Namgaladze D,Weigert A,Dehne N,Brüne B

更新日期：2009-09-03 00:00:00

abstract：:Vascular cell adhesion molecule-1 (VCAM-1) and endothelial-leukocyte adhesion molecule-1 (ELAM-1) are adhesive proteins induced on endothelium by cytokines. We examined the contribution of these adhesive proteins to human peripheral blood monocyte adherence to endothelium using transfected Chinese hamster ovary (CHO) ...

journal_title：Blood

authors： Carlos T,Kovach N,Schwartz B,Rosa M,Newman B,Wayner E,Benjamin C,Osborn L,Lobb R,Harlan J

更新日期：1991-05-15 00:00:00

abstract：:We have demonstrated that high molecular weight kininogen (HK) binds specifically on endothelial cells to domain 2/3 of the urokinase receptor (uPAR). Inhibition by vitronectin suggests that kallikrein-cleaved HK (HKa) is antiadhesive. Plasma kallikrein bound to HK cleaves prourokinase to urokinase, initiating cell-as...

journal_title：Blood

authors： Colman RW,Jameson BA,Lin Y,Johnson D,Mousa SA

更新日期：2000-01-15 00:00:00

abstract：:Dosing of enzyme replacement therapy (ERT) for Gaucher disease type 1 is still a subject of debate and varies from 15 to 130 U/kg/mo, making a huge economic difference of 70,000 US dollars to 380,000 US dollars(euro55,000-300,000) per patient per year. To investigate whether this difference in dosing ultimately transl...

journal_title：Blood

authors： de Fost M,Hollak CE,Groener JE,Aerts JM,Maas M,Poll LW,Wiersma MG,Häussinger D,Brett S,Brill N,vom Dahl S

更新日期：2006-08-01 00:00:00

abstract：:The peripheral blood lymphocytes from 42 patients with multiple myeloma (MM) and 13 patients with monoclonal gammopathy of undetermined significance (MGUS) were studied by three-color immunofluorescence (IF) using antibodies directed to a broad range of B-cell markers (CD19, CD20, CD21, CD24), CALLA (CD10), PCA-1 (a p...

journal_title：Blood

authors： Jensen GS,Mant MJ,Belch AJ,Berenson JR,Ruether BA,Pilarski LM

更新日期：1991-08-01 00:00:00

abstract：:In this report, we show that the Src family nonreceptor protein tyrosine kinase (PTK) Lyn associates with aggregated IgA Fc receptor (Fc alpha R) in the monocytic cell line THP-1. Receptor aggregation and subsequent immunoprecipitation of receptor complexes with huIgA adsorbed to nitrocellulose particles shows that Ly...

journal_title：Blood

authors： Gulle H,Samstag A,Eibl MM,Wolf HM

更新日期：1998-01-15 00:00:00

abstract：:Pediatric myelodysplastic syndromes (MDSs) are a heterogeneous group of clonal disorders with an annual incidence of 1 to 4 cases per million, accounting for less than 5% of childhood hematologic malignancies. MDSs in children often occur in the context of inherited bone marrow failure syndromes, which represent a pec...

journal_title：Blood

authors： Locatelli F,Strahm B

更新日期：2018-03-29 00:00:00

abstract：:BCL3 encodes a protein with close homology to IkappaB proteins and interacts with p50 NF-kappaB homodimers. However, the regulation and transcriptional activity of BCL3 remain ill-defined. We observed here that interleukin-9 (IL-9) and IL-4, but not IL-2 or IL-3, transcriptionally upregulated BCL3 expression in T cell...

journal_title：Blood

authors： Richard M,Louahed J,Demoulin JB,Renauld JC

更新日期：1999-06-15 00:00:00

abstract：:Deletions at the 3' end of the human beta-globin locus are associated with the hereditary persistence of fetal hemoglobin (HPFH) in adults, potentially through the juxtaposition of enhancer elements in the vicinity of the fetal gamma-globin genes. We have tested how sequences at the HPFH-2, HPFH-3, and HPFH-6 breakpoi...

journal_title：Blood

authors： Katsantoni EZ,Langeveld A,Wai AW,Drabek D,Grosveld F,Anagnou NP,Strouboulis J

更新日期：2003-11-01 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) signaling pathway is an essential regulator of cellular processes, including proliferation, differentiation, migration, and cell survival. During hematopoiesis, the TGF-beta signaling pathway is a potent negative regulator of proliferation while stimulating differentiatio...

journal_title：Blood

authors： Dong M,Blobe GC

更新日期：2006-06-15 00:00:00

abstract：:Alternatively activated macrophages (AAMϕ) are a major component of the response to helminth infection; however, their functions remain poorly defined. To better understand the helminth-induced AAMϕ phenotype, we performed a systems-level analysis of in vivo derived AAMϕ using an established mouse model. With next-gen...

journal_title：Blood

authors： Thomas GD,Rückerl D,Maskrey BH,Whitfield PD,Blaxter ML,Allen JE

更新日期：2012-12-13 00:00:00

abstract：:Rh blood group antigens of the D, C/c, and E/e series are carried by at least three red cell membrane polypeptides encoded by two highly related genes, RHD and RHCE. Homozygous individuals carrying the D--, Dc-, and DCw- gene complexes are characterized by a total or partial lack of expression of the RHCE-encoded anti...

journal_title：Blood

authors： Chérif-Zahar B,Raynal V,D'Ambrosio AM,Cartron JP,Colin Y

更新日期：1994-12-15 00:00:00

abstract：:The causes of anemia and immunosuppression, major outcomes of malaria, are not well established. This study was undertaken to investigate whether erythropoietin (EP) production is adequate and whether the hemopoietic stem cells (CFU-S) were affected during the course of infection. Groups of female Balb/c mice infected...

journal_title：Blood

authors： Silverman PH,Schooley JC,Mahlmann LJ

更新日期：1987-02-01 00:00:00

abstract：:The novel immunosuppressant FTY720 activates sphingosine 1-phosphate receptors (S1PRs) that affect responsiveness of lymphocytes to chemokines such as stromal cell-derived factor 1 (SDF-1), resulting in increased lymphocyte homing to secondary lymphoid organs. Since SDF-1 and its receptor CXCR4 are also involved in bo...

journal_title：Blood

authors： Kimura T,Boehmler AM,Seitz G,Kuçi S,Wiesner T,Brinkmann V,Kanz L,Möhle R

更新日期：2004-06-15 00:00:00

abstract：:We have determined the 2905 nucleotide sequence of the rhesus macaque factor IX complementary DNA (cDNA) and found it to be greater than 95% identical to that of the human factor IX cDNA. The cDNA has a large 3' untranslated region like the human cDNA, but unlike the human cDNA has two polyadenylation sites 224 nucleo...

journal_title：Blood

authors： Lozier JN,Metzger ME,Donahue RE,Morgan RA

更新日期：1999-03-15 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:Omenn syndrome (OS) is an inherited disorder characterized by an absence of circulating B cells and an infiltration of the skin and the intestine by activated oligoclonal T lymphocytes, indicating that a profound defect in the lymphoid developmental program could be accountable for this condition. Inherited mutations ...

journal_title：Blood

authors： Corneo B,Moshous D,Güngör T,Wulffraat N,Philippet P,Le Deist FL,Fischer A,de Villartay JP

更新日期：2001-05-01 00:00:00

abstract：:Cytotoxic T lymphocytes (CTLs) can kill target cells by the granule/exocytosis pathway or the Fas-mediated apoptosis pathway. The sensitivity of chronic lymphocytic leukemia (CLL) B cells to CTL-mediated apoptosis before and after CD40 activation was examined. Resting or CD40-activated CLL cells were found to be equal...

journal_title：Blood

authors： Chu P,Wierda WG,Kipps TJ

更新日期：2000-06-15 00:00:00

abstract：:Primary graft rejection after marrow transplantation occurs more frequently in patients receiving HLA-haploidentical compared with HLA-identical sibling transplants. Both human and experimental animal data suggest that the cells responsible for this phenomenon are either host natural killer (NK) cells, T cells, or bot...

journal_title：Blood

authors： Sandmaier BM,Storb R,Bennett KL,Appelbaum FR,Santos EB

更新日期：1998-05-01 00:00:00

abstract：:Classical hairy cell leukemia (cHCL) is characterized by a near 100% frequency of the BRAFV600E mutation, whereas ∼30% of variant HCLs (vHCLs) have MAP2K1 mutations. However, recurrent genetic alterations cooperating with BRAFV600E or MAP2K1 mutations in HCL, as well as those in MAP2K1 wild-type vHCL, are not well def...

journal_title：Blood

authors： Durham BH,Getta B,Dietrich S,Taylor J,Won H,Bogenberger JM,Scott S,Kim E,Chung YR,Chung SS,Hüllein J,Walther T,Wang L,Lu SX,Oakes CC,Tibes R,Haferlach T,Taylor BS,Tallman MS,Berger MF,Park JH,Zenz T,Abdel-Waha

更新日期：2017-10-05 00:00:00

abstract：:The tyrosine kinase receptor fetal liver kinase 1 (Flk-1) plays a crucial role in vasculogenesis and angiogenesis, but its target genes remain elusive. Comparing Flk-1(+/+) with Flk-1(-/-) embryonic stem (ES) cells, we identified transcripts regulated by the vascular endothelial growth factor A (VEGF-A)/Flk-1 pathway ...

journal_title：Blood

authors： Zippo A,De Robertis A,Bardelli M,Galvagni F,Oliviero S

更新日期：2004-06-15 00:00:00

abstract：:Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20 spontaneous CLL regression cases incorporating phenotypic, functional, transcriptomic, and genomic studie...

journal_title：Blood

authors： Kwok M,Oldreive C,Rawstron AC,Goel A,Papatzikas G,Jones RE,Drennan S,Agathanggelou A,Sharma-Oates A,Evans P,Smith E,Dalal S,Mao J,Hollows R,Gordon N,Hamada M,Davies NJ,Parry H,Beggs AD,Munir T,Moreton P,Paneesha

更新日期：2020-02-06 00:00:00

abstract：:Sixty-five patients with hairy cell leukemia underwent splenectomy; 27 had a complete remission as defined by a return in WBC, RBC, and platelet counts to a defined level, and 38 had a partial remission with a return of only one or two of these parameters to the defined level. The 5-yr actuarial survival for all patie...

journal_title：Blood

authors： Golomb HM,Vardiman JW

更新日期：1983-02-01 00:00:00

abstract：:Electrolyte disturbances in leukemia can be the result of the disease process or drug therapy. One group of electrolyte abnormalities is related to the stage of the leukemic process. Included in this group are newly diagnosed patients who may show elevated serum potassium, phosphorus, and magnesium--a result of their ...

journal_title：Blood

authors： O'Regan S,Carson S,Chesney RW,Drummond KN

更新日期：1977-03-01 00:00:00