Sustained human hematopoiesis in immunodeficient mice by cotransplantation of marrow stroma expressing human interleukin-3: analysis of gene transduction of long-lived progenitors.

abstract：:Stem cell factor (SCF) binding to the c-kit receptor triggers homodimerization and intermolecular tyrosine phosphorylation of the c-kit receptor, thus initiating signal transduction. Receptor dimerization is a critical early step in this process. Prior biochemical studies of c-kit receptor dimerization have mainly use...

journal_title：Blood

authors： Broudy VC,Lin NL,Bühring HJ,Komatsu N,Kavanagh TJ

更新日期：1998-02-01 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells frequently resist apoptosis induction by chemotherapeutic agents; however, the mechanism of unresponsiveness has not been elucidated. Here, we show that cytochrome c fails to stimulate apop...

journal_title：Blood

authors： Sun Y,Orrenius S,Pervaiz S,Fadeel B

更新日期：2005-05-15 00:00:00

abstract：:To program pluripotent cells into blood, a knowledge of the locations of precursors during their journey through the embryo and the signals they experience would be informative. The anterior (a) and posterior (p) ventral blood islands (VBIs) in Xenopus are derived from opposite sides of the pregastrula embryo. The aVB...

journal_title：Blood

authors： Walmsley M,Cleaver D,Patient R

更新日期：2008-02-01 00:00:00

abstract：:Increased apoptosis of CD4+ T cells is considered to be involved in CD4+ T-cell depletion in human immunodeficiency virus type-1 (HIV-1)-infected individuals progressing toward acquired immunodeficiency syndrome (AIDS). We have recently shown that CD95 (APO-1/Fas) expression is strongly increased in T cells of HIV-1-i...

journal_title：Blood

authors： Bäumler CB,Böhler T,Herr I,Benner A,Krammer PH,Debatin KM

更新日期：1996-09-01 00:00:00

abstract：:Asparaginase is an enzyme used in the treatment of acute lymphoblastic leukemia and lymphoblastic lymphoma in children. It has minimal bone marrow toxicity. Its major side effects are anaphylaxis, pancreatitis, diabetes, coagulation abnormalities, and thrombosis, especially intracranial. It is derived from 2 different...

journal_title：Blood

authors： Duval M,Suciu S,Ferster A,Rialland X,Nelken B,Lutz P,Benoit Y,Robert A,Manel AM,Vilmer E,Otten J,Philippe N

更新日期：2002-04-15 00:00:00

abstract：:We report a novel t(7;9)(q11;p13) translocation in 2 patients with B-cell acute lymphoblastic leukemia (B-ALL). By fluorescent in situ hybridization and 3' rapid amplification of cDNA ends, we showed that the paired box domain of PAX5 was fused with the elastin (ELN) gene. After cloning the full-length cDNA of the chi...

journal_title：Blood

authors： Bousquet M,Broccardo C,Quelen C,Meggetto F,Kuhlein E,Delsol G,Dastugue N,Brousset P

更新日期：2007-04-15 00:00:00

abstract：:Isocitrate dehydrogenase 1 mutation (IDH1-R132H) was recently identified in acute myeloid leukemia with normal cytogenetics. The mutant enzyme is thought to convert α-ketoglutarate to the pathogenic 2-hydroxyglutarate (2-HG) that affects DNA methylation via inhibition of ten-eleven translocation 2. However, the role o...

journal_title：Blood

authors： Shi X,He BL,Ma AC,Guo Y,Chi Y,Man CH,Zhang W,Zhang Y,Wen Z,Cheng T,Leung AY

更新日期：2015-05-07 00:00:00

abstract：:The molecular basis of different outcomes in pediatric acute lymphoblastic leukemia (ALL) remains poorly understood. We addressed the clinical significance and mechanisms behind in vitro cellular responses to ionizing radiation (IR)-induced DNA double-strand breaks in 74 pediatric patients with ALL. We found an apopto...

journal_title：Blood

authors： Marston E,Weston V,Jesson J,Maina E,McConville C,Agathanggelou A,Skowronska A,Mapp K,Sameith K,Powell JE,Lawson S,Kearns P,Falciani F,Taylor M,Stankovic T

更新日期：2009-01-01 00:00:00

abstract：:We have examined the effects of administration of stem cell-factor (SCF) on the number and distribution of pluripotent hematopoietic stem cells (PHSC) in normal mice. Using the competitive repopulation assay we found that in vivo administration of SCF increases the absolute number of PHSC per mouse threefold. The incr...

journal_title：Blood

authors： Bodine DM,Seidel NE,Zsebo KM,Orlic D

更新日期：1993-07-15 00:00:00

abstract：:We explored adeno-associated viral vector (AAV)-mediated gene transfer in the perinatal period in animal models of severe congenital factor VII (FVII) deficiency, a disease associated with early postnatal life-threatening hemorrhage. In young adult mice with plasma FVII < 1% of normal, a single tail vein administratio...

journal_title：Blood

authors： Binny C,McIntosh J,Della Peruta M,Kymalainen H,Tuddenham EG,Buckley SM,Waddington SN,McVey JH,Spence Y,Morton CL,Thrasher AJ,Gray JT,Castellino FJ,Tarantal AF,Davidoff AM,Nathwani AC

更新日期：2012-01-26 00:00:00

abstract：:Tumor-infiltrating T lymphocytes (TIL-T) are always present in B-cell-derived non-Hodgkin's lymphoma (NHL). In this investigation, we explored the possibility that collaboration might exist between these cells. TIL-T were isolated from 39 lymph nodes of patients with NHL. In most of the cases, few of them (less than 1...

journal_title：Blood

authors： Jacob MC,Piccinni MP,Bonnefoix T,Sotto MF,Couderc P,Bensa JC,Sotto JJ

更新日期：1990-03-01 00:00:00

abstract：:The transcription factor runt-related transcription factor 1 (Runx1) is essential for the establishment of definitive hematopoiesis during embryonic development. In adult blood homeostasis, Runx1 plays a pivotal role in the maturation of lymphocytes and megakaryocytes. Furthermore, Runx1 is required for the regulation...

journal_title：Blood

authors： Ross K,Sedello AK,Todd GP,Paszkowski-Rogacz M,Bird AW,Ding L,Grinenko T,Behrens K,Hubner N,Mann M,Waskow C,Stocking C,Buchholz F

更新日期：2012-05-03 00:00:00

abstract：:The transcription factor encoded by the mi locus (MITF) is a transcription factor of the basic-helix-loop-helix zipper protein family. Mice of mi/mi genotype express a normal amount of abnormal MITF, whereas mice of tg/tg genotype do not express any MITFs due to the transgene insertional mutation. The effect of normal...

journal_title：Blood

authors： Ogihara H,Morii E,Kim DK,Oboki K,Kitamura Y

更新日期：2001-02-01 00:00:00

abstract：:The majority of mouse Vα14 invariant natural killer T (Vα14i NKT) cells produce several cytokines, including IFNγ and IL-4, very rapidly after activation. A subset of these cells, known as NKT17 cells, however, differentiates in the thymus to preferentially produce IL-17. Here, we show that the transcription factor-kn...

journal_title：Blood

authors： Engel I,Zhao M,Kappes D,Taniuchi I,Kronenberg M

更新日期：2012-11-29 00:00:00

abstract：:B-cell chronic lymphocytic leukemia (CLL) consists of 2 prognostic entities where cases with mutated immunoglobulin V(H) genes have better outcome than unmutated cases. V(H)-mutated CLLs display longer telomeres compared with unmutated cases and telomere length has been indicated to predict outcome, although the progn...

journal_title：Blood

authors： Grabowski P,Hultdin M,Karlsson K,Tobin G,Aleskog A,Thunberg U,Laurell A,Sundström C,Rosenquist R,Roos G

更新日期：2005-06-15 00:00:00

abstract：:One obstacle to retrovirus-mediated gene therapy for human hematopoietic disorders is the low efficiency of gene transfer into pluripotent hematopoietic stem cells (HSC). We have previously shown a direct correlation between retrovirus receptor mRNA levels in mouse HSC and the efficiency with which they are transduced...

journal_title：Blood

authors： Orlic D,Girard LJ,Anderson SM,Pyle LC,Yoder MC,Broxmeyer HE,Bodine DM

更新日期：1998-05-01 00:00:00

abstract：:Activation of endothelial cells, important in processes such as angiogenesis, is regulated by cell surface receptors, including those in the tyrosine kinase (RTK) family. Receptor activity, in turn, can be modulated by phosphorylation, turnover, or proteolytic release of a soluble extracellular domain. Previously, we ...

journal_title：Blood

authors： Yabkowitz R,Meyer S,Black T,Elliott G,Merewether LA,Yamane HK

更新日期：1999-03-15 00:00:00

abstract：:Most anticancer chemotherapies are immunosuppressive and induce nonimmunogenic tumor cell death. Bortezomib, a specific inhibitor of 26S proteasome, has shown clinical activity in several human tumors, including myeloma. Here we show that the uptake of human myeloma cells by dendritic cells (DCs) after tumor cell deat...

journal_title：Blood

authors： Spisek R,Charalambous A,Mazumder A,Vesole DH,Jagannath S,Dhodapkar MV

更新日期：2007-06-01 00:00:00

abstract：:We have investigated the structure of the Ig heavy (IGH) chain locus in 309 cases of acute leukemia. Seventy-one cases of B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) were analyzed: in six cases deletion of joining (JH) segments in the presence of cytogenetically normal chromosome 14 was observed. Similar...

journal_title：Blood

authors： Dyer MJ,Heward JM,Zani VJ,Buccheri V,Catovsky D

更新日期：1993-08-01 00:00:00

abstract：:Human platelets are aggregated and induced to release their granule contents and form thromboxane by peptides as short as 6-amino acid residues (SFLLRN) corresponding to the newly released N-terminus of the thrombin receptor that is cleaved by thrombin. Using washed platelets, we found that these responses to SFLLRN (...

journal_title：Blood

authors： Kinlough-Rathbone RL,Rand ML,Packham MA

更新日期：1993-07-01 00:00:00

abstract：:AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is selectively expressed on CD34(bright) hematopoietic stem and progenitor cells (progenitors) derived from human fetal liver and b...

journal_title：Blood

authors： Yin AH,Miraglia S,Zanjani ED,Almeida-Porada G,Ogawa M,Leary AG,Olweus J,Kearney J,Buck DW

更新日期：1997-12-15 00:00:00

abstract：:One of the most serious complications of successful treatments for Hodgkin's disease is an increased incidence of acute nonlymphocytic leukemia (ANLL) and other malignancies. A retrospective analysis carried out on 1032 consecutive patients with Hodgkin's disease admitted to our Institute between 1965 and 1978 and tre...

journal_title：Blood

authors： Valagussa P,Santoro A,Fossati Bellani F,Franchi F,Banfi A,Bonadonna G

更新日期：1982-03-01 00:00:00

abstract：:From ten patients with advanced malignant disease involving the bone marrow, autologous hematopoietic stem cells were collected from the peripheral blood during eight four-hour pheresis procedures and cryopreserved. No manipulations to increase the number of stem cells circulating in the blood were used during the col...

journal_title：Blood

authors： Kessinger A,Armitage JO,Landmark JD,Smith DM,Weisenburger DD

更新日期：1988-03-01 00:00:00

abstract：:Repeated analysis of peripheral blood lymphocytes (PBLs) from a patient with large granular lymphocytosis, neutropenia, and rheumatoid arthritis revealed that approximately 45% of PBLs displayed the following phenotype: CD3+, CD4-, CD8-, CD16+, HNK-1-, WT31-. This population was purified for further analysis by deplet...

journal_title：Blood

authors： Vie H,Chevalier S,Garand R,Moisan JP,Praloran V,Devilder MC,Moreau JF,Soulillou JP

更新日期：1989-07-01 00:00:00

abstract：:Surprisingly little is known about the interaction of human blood mononuclear cells with viruses. Here, we show that monocytes are the predominant cell type infected when peripheral blood mononuclear cells are exposed to viruses ex vivo. Remarkably, infection with vesicular stomatitis virus, vaccinia virus, and a vari...

journal_title：Blood

authors： Hou W,Gibbs JS,Lu X,Brooke CB,Roy D,Modlin RL,Bennink JR,Yewdell JW

更新日期：2012-03-29 00:00:00

abstract：:Prolylcarboxypeptidase (PRCP) activates prekallikrein to plasma kallikrein, leading to bradykinin liberation, and degrades angiotensin II. We now identify PRCP as a regulator of blood vessel homeostasis. β-Galactosidase staining in PRCP(gt/gt) mice reveals expression in kidney and vasculature. Invasive telemetric moni...

journal_title：Blood

authors： Adams GN,LaRusch GA,Stavrou E,Zhou Y,Nieman MT,Jacobs GH,Cui Y,Lu Y,Jain MK,Mahdi F,Shariat-Madar Z,Okada Y,D'Alecy LG,Schmaier AH

更新日期：2011-04-07 00:00:00

abstract：:Genetic analysis of hemochromatosis has led to the discovery of a number of genes whose mutations disrupt iron homeostasis and lead to iron overload. The introduction of molecular tests into clinical practice has provided a tool for early diagnosis of these conditions. It has become clear that hemochromatosis includes...

journal_title：Blood

authors： Camaschella C

更新日期：2005-12-01 00:00:00

abstract：:Laminin is a heterotrimeric glycoprotein that plays a central role in promoting neutrophil chemotaxis, motility, and attachment to basement membrane. Rabbit peritoneal exudate neutrophils stain positively for laminin, which is presumed to be of exogenous origin and bound to laminin receptors on the cell surface. We ex...

journal_title：Blood

authors： Tweardy DJ,Sasaki M,Cardamone JJ Jr,McCoy JP Jr,Bonidie MJ,Signorella AP

更新日期：1990-10-01 00:00:00

abstract：:Patients with severe aplastic anemia were conditioned with cyclophosphamide (200 mg/kg) and given marrow grafts from HLA-identical family members. Among 233 patients transplanted, 225 survived greater than or equal to 14 days and could be evaluated for engraftment. Forty-four of the 225 rejected their graft; 33 of the...

journal_title：Blood

authors： Deeg HJ,Self S,Storb R,Doney K,Appelbaum FR,Witherspoon RP,Sullivan KM,Sheehan K,Sanders J,Mickelson E

更新日期：1986-12-01 00:00:00

abstract：:Acetylcholinesterase (AChE) was long thought to be an enzyme found specifically at the sites of nerve synapses and neuromuscular junctions. It has also been found to occur, however, in cells that are not involved with neurotransmission. This study presents the ultrastructural localization of AChE activity in human thy...

journal_title：Blood

authors： Topilko A,Caillou B

更新日期：1985-10-01 00:00:00