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Structure-activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors.

Abstract：

:The structure-activity relationship of a number of synthetic green tea polyphenol analogs involving modifications of A ring and B ring of epi-gallocatechin gallate (EGCG) as proteasome inhibitors has been examined. It was found that in B ring, a decrease in the number of OH groups led to decreased potency. Introduction of a hydrophobic benzyl group into the 8 position of A ring did not significantly affect the proteasome-inhibitory potency.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Wan SB,Landis-Piwowar KR,Kuhn DJ,Chen D,Dou QP,Chan TH

doi

10.1016/j.bmc.2004.12.056

subject

Has Abstract

pub_date

2005-03-15 00:00:00

pages

2177-85

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(05)00011-8

journal_volume

13

pub_type

杂志文章

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