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A genetically selected cyclic peptide inhibitor of BCL6 homodimerization.

Abstract：

:We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexapeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Osher EL,Castillo F,Elumalai N,Waring MJ,Pairaudeau G,Tavassoli A

doi

10.1016/j.bmc.2018.03.012

subject

Has Abstract

pub_date

2018-07-15 00:00:00

pages

3034-3038

issue

11

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(18)30254-2

journal_volume

26

pub_type

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