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Generation of hazardous methyl azide and its application to synthesis of a key-intermediate of picarbutrazox, a new potent pesticide in flow.

Abstract：

:Generation and reactions of methyl azide (MeN3) were successfully performed by using a flow reactor system, demonstrating that the flow method serves as a safe method for handling hazardous explosive methyl azide. The reaction of NaN3 and Me2SO4 in a flow reactor gave a MeN3 solution, which was used for Huisgen reaction with benzoyl cyanide in a flow reactor after minimal washing. The resulting 1-methyl-5-benzoyltetrazole serves as a key intermediate of picarbutrazox (IX), a new potent pesticide.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ichinari D,Nagaki A,Yoshida JI

doi

10.1016/j.bmc.2017.07.005

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

6224-6228

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)31363-9

journal_volume

25

pub_type

杂志文章

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