Abstract:
:Twelve new flavanones bearing a 2,2-dimethylpyrano ring were isolated from a MeOH extract of the stem bark of Erythrina abyssinica. Their structures were determined on the basis of spectroscopic (UV, CD, 1D and 2D NMR, HRMS) and physico-chemical analyses. Compounds 1, 3, 5, 6, 8, and 9 exhibited inhibitory effects on the enzyme activity of PTP1B in an in vitro assay with IC(50) values ranging from 13.9+/-2.1 to 19.0+/-1.8 microM. These results suggest that prenyl and methoxy groups on the B ring contribute to the inhibitory activity of flavanones against PTP1B.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Cui L,Thuong PT,Lee HS,Ndinteh DT,Mbafor JT,Fomum ZT,Oh WKdoi
10.1016/j.bmc.2008.10.012subject
Has Abstractpub_date
2008-12-15 00:00:00pages
10356-62issue
24eissn
0968-0896issn
1464-3391pii
S0968-0896(08)00951-6journal_volume
16pub_type
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