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Exploring a synthetic organoselenium compound for antioxidant pharmacotherapy--toxicity and effects on ROS-production.

Abstract：

:The organoselenium antioxidant 1 was previously found to act as a catalytic antioxidant in a two-phase lipid peroxidation system. In aqueous environment, selenide 1 quenched ABTS-radicals more efficiently than Trolox and ascorbic acid. The selenide dose-dependently scavenged reactive oxygen and nitrogen species more efficiently than Trolox for neutrophils and PMA-stimulated macrophages, with 50% inhibitory concentrations in the low micromolar range. In addition no sign of toxicity or effect on cell viability was seen when culturing five human cell lines in concentrations up to 200 microM of selenide 1 for up to seven days. We therefore feel that the compound would be a good candidate for future drug development for prevention or treatment of disorders caused by or involving free radical-mediated or oxidative tissue damage.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Johansson H,Svartström O,Phadnis P,Engman L,Ott MK

doi

10.1016/j.bmc.2010.01.057

subject

Has Abstract

pub_date

2010-03-01 00:00:00

pages

1783-8

issue

5

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00088-X

journal_volume

18

pub_type

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