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Syntheses of ferulic acid derivatives and their suppressive effects on cyclooxygenase-2 promoter activity.

Abstract：

:Novel ferulic acid derivatives in which feruloyl groups were attached to the hydroxyl groups of myo-inositol 1,3,5-orthoformate derivatives were synthesized. These feruloyl-myo-inositols suppressed the cyclooxygenase-2 (COX-2) promoter activity in a concentration-dependent manner. Among the examined compounds, compound 9 showed the highest activity. A treatment with 100 microM of compound 9 for 24 h resulted in a 50% decrease of COX-2 promoter activity without marked cytotoxicity. Both the molecular structure in which two ferulic acid moieties are facing each other and the molecular hydrophobicity may be essential for the suppression of COX-2 promoter activity.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Hosoda A,Ozaki Y,Kashiwada A,Mutoh M,Wakabayashi K,Mizuno K,Nomura E,Taniguchi H

doi

10.1016/s0968-0896(01)00386-8

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

1189-96

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968089601003868

journal_volume

10

pub_type

杂志文章

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