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Antioxidant activity of benzoxazolinonic and benzothiazolinonic derivatives in the LDL oxidation model.

Abstract：

:A series of benzazolone compounds were synthesized utilizing benzoxazolinonic and benzothiazolinonic heterocycles as the building unit. The antioxidant activity of these compounds was determined by inhibition of lipid peroxidation. The oxidation of LDL was induced in the presence of CuSO(4) or 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH). The protective action of these compounds against the cytotoxicity was evaluated with lactate dehydrogenase (LDH) activity in bovine aortic endothelial cells (BAECs) and cellular vitality by measuring mitochondrial activity in the presence of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide). The best antioxidant activities were observed for phenolic compounds 13 and 14b with ratio R=2.5, 3.2 (5microM). Both of these test substances increased the cell viability significantly as indicated by MTT assay and LDH release assay.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Yekini I,Hammoudi F,Martin-Nizard F,Yous S,Lebegue N,Berthelot P,Carato P

doi

10.1016/j.bmc.2009.09.016

subject

Has Abstract

pub_date

2009-11-15 00:00:00

pages

7823-30

issue

22

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00868-2

journal_volume

17

pub_type

杂志文章

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