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The selective quantification of iron by hexadentate fluorescent probes.

Abstract：

:The synthesis of four hexadentate fluorescent probes is described, where the fluorescent moiety is based on either coumarin or fluorescein and the chelating moiety is based on either 3-hydroxypyridin-4-one or 3-hydroxypyran-4-one. The fluorescence is quenched when the probe chelating moieties bind iron. The probes were found to be selective for iron over other metals such as Cu, Zn, Ni, Mn and Co. The effect of Cu on fluorescence quenching can be eliminated in the presence of N,N,N',N'-tetrakis(2-pyridylmethyl)-ethylenediamine. Competition studies demonstrate that the exchange of iron between pyridinone-based probes and apotransferrin is very slow. The ability to scavenge iron from oligomeric iron(III) citrate complexes demonstrate that the pyridinone probes scavenges iron faster than deferiprone and desferrioxamine. The fluorescence intensity of the fluorescein-based probe is quantitatively related to the iron concentration with the limit of detection being 10(-8)M.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ma YM,Hider RC

doi

10.1016/j.bmc.2009.09.052

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

8093-101

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00918-3

journal_volume

17

pub_type

杂志文章

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