Abstract:
:6-N-(Benzothiazol-2-yl)deoxyadenosine (A(BT)) was synthesized and incorporated into DNAs. Although, the multipoint benzothiazole (BT) modification of oligodeoxynucleotides reduced the stability of duplexes with their complementary strands, it induced the strong exciton coupling between BT moieties. The circular dichroism (CD) spectra of this exciton coupling interaction were observed at wavelengths above 300nm and overlapping with the UV absorption bands of nucleotides could be avoided. The shapes of the CD spectra due to this interaction were strongly influenced by the helicity of two BT groups.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Masaki Y,Ohkubo A,Seio K,Sekine Mdoi
10.1016/j.bmc.2009.12.009subject
Has Abstractpub_date
2010-01-15 00:00:00pages
567-72issue
2eissn
0968-0896issn
1464-3391pii
S0968-0896(09)01093-1journal_volume
18pub_type
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