Synthesis of (R)- or (S)-valinol using ω-transaminases in aqueous and organic media.


:Valinol is part of numerous pharmaceuticals and has various other important applications. Optically pure valinol (ee >99%) was prepared employing different ω-transaminases from the corresponding prochiral hydroxy ketone. By the choice of the enzyme the (R)- as well as the (S)-enantiomer were accessible. Reductive amination was performed in organic solvent (MTBE) using 2-propyl amine as amine donor whereas alanine was applied in or in aqueous medium. Transformations in phosphate buffer were successfully performed even at 200 mM substrate concentration (20.4 g/L) leading to 99% (R) and 94% (S) conversion with perfect optical purity (>99% ee).


Bioorg Med Chem


Fuchs CS,Simon RC,Riethorst W,Zepeck F,Kroutil W




Has Abstract


2014-10-15 00:00:00














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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Bioorganic & medicinal chemistry

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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


    authors: Bartolozzi A,Li B,Franck RW

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    pub_type: 杂志文章


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    journal_title:Bioorganic & medicinal chemistry

    pub_type: 杂志文章


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    更新日期:2014-06-15 00:00:00