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Synthesis and antiviral evaluation of 2-amino-6-carbamoylpurine dioxolane nucleoside derivatives and their phosphoramidates prodrugs.

Abstract：

:The synthesis of 9-(β-d-1,3-dioxolan-4-yl)2,6-diaminopurine nucleoside phosphoramidate prodrugs as well as various 2-amino-6-carbamoylpurine dioxolane derivatives and their phosphoramidates prodrugs is reported. Their ability to block HIV and HBV replication along with their cytotoxicity toward HepG2, human lymphocyte, CEM and Vero cells was also assessed.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Cho JH,Bondana L,Detorio MA,Montero C,Bassit LC,Amblard F,Coats SJ,Schinazi RF

doi

10.1016/j.bmc.2014.10.003

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

6665-6671

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(14)00716-0

journal_volume

22

pub_type

杂志文章

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