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The adduct formation between the thioguanine-polyamine ligands and DNA with the AP site under UVA irradiated and non-irradiated conditions.

Abstract：

:The AP sites are representative of DNA damage and known as an intermediate in the base excision repair (BER) pathway which is involved in the repair of damaged nucleobases by reactive oxygen species, UVA irradiation, and DNA alkylating agents. Therefore, it is expected that the inhibition or modulation of the AP site repair pathway may be a new type of anticancer drug. In this study, we investigated the effects of the thioguanine-polyamine ligands (SG-ligands) on the affinity and the reactivity for the AP site under UVA irradiated and non-irradiated conditions. The SG-ligands have a photo-reactivity with the A-F-C sequence where F represents a tetrahydrofuran AP site analogue. Interestingly, the SG-ligands promoted the β-elimination of the AP site followed by the formation of a covalent bond with the β-eliminated fragment without UVA irradiation.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Abe YS,Sasaki S

doi

10.1016/j.bmc.2019.115160

subject

Has Abstract

pub_date

2019-12-15 00:00:00

pages

115160

issue

24

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(19)31280-5

journal_volume

27

pub_type

杂志文章

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