Development of polymeric drug delivery system for recognizing vascular endothelial dysfunction.

Abstract:

:The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.

journal_name

Bioorg Med Chem

authors

Ikuta K,Mori T,Yamamoto T,Niidome T,Shimokawa H,Katayama Y

doi

10.1016/j.bmc.2008.01.006

subject

Has Abstract

pub_date

2008-03-15 00:00:00

pages

2811-8

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(08)00007-2

journal_volume

16

pub_type

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