Abstract:
:The vascular endothelium plays an important role in regulating vascular homeostasis. Damage to the endothelium can lead to cardiovascular diseases such as arteriosclerosis. Therefore, early-stage detection and evaluation of vascular endothelium dysfunction would be very important for effective diagnosis and therapy. We synthesized a polymeric drug carrier bearing an Evans blue analogue as a probing unit for endothelium injury. The polymeric carrier spontaneously formed stable nanoparticles with micelle-like structure in aqueous media and could encapsulate hydrophobic doxorubicin (DOX). The encapsulated DOX showed a sustainable release profile over a period of 10-60 h depending on the loaded DOX concentration. The polymeric carrier specifically adsorbed against the endothelium-injured site in extracted porcine aorta. These properties of the polymeric drug carrier will be suitable for specific drug delivery to endothelium dysfunctional region.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Ikuta K,Mori T,Yamamoto T,Niidome T,Shimokawa H,Katayama Ydoi
10.1016/j.bmc.2008.01.006subject
Has Abstractpub_date
2008-03-15 00:00:00pages
2811-8issue
6eissn
0968-0896issn
1464-3391pii
S0968-0896(08)00007-2journal_volume
16pub_type
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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更新日期:2007-07-15 00:00:00
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