A new dihydroxanthenone from a plant-associated strain of the fungus Chaetomium globosum demonstrates anticancer activity.

Abstract:

:Bioassay-guided fractionation of a cytotoxic EtOAc extract of the fungal strain, Chaetomium globosum, inhabiting the rhizosphere of the Christmas cactus, Opuntia leptocaulis, of the Sonoran desert afforded a new dihydroxanthenone, globosuxanthone A (1), a new tetrahydroxanthenone, globosuxanthone B (2), two new xanthones, globosuxanthone C (3) and D (4), 2-hydroxyvertixanthone (5), and two known anthraquinones (6 and 7). The structures of the new compounds 1-4 were elucidated by NMR and MS techniques, and the relative stereochemistry of 1 was determined by X-ray crystallographic analysis. Of the compounds encountered, 1 was found to exhibit strong cytotoxicity against a panel of seven human solid tumor cell lines, disrupt the cell cycle leading to the accumulation of cells in either G2/M or S phase, and induce classic signs of apoptosis.

journal_name

Bioorg Med Chem

authors

Wijeratne EM,Turbyville TJ,Fritz A,Whitesell L,Gunatilaka AA

doi

10.1016/j.bmc.2006.07.048

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

7917-23

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00601-8

journal_volume

14

pub_type

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