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Synthesis and antidepressant-like action of stereoisomers of imidobenzenesulfonylaziridines in mice evaluated in the forced swimming test.

Abstract：

:The present study describes the chemical synthesis and pharmacological evaluation of a new series of eleven compounds stereoisomers of imidobenzenesulfonylaziridines in the forced-swimming test (FST) in mice. The pharmacological results of these compounds show that six of them, given intraperitoneally, reduced the immobility time of mice evaluated in the FST, an antidepressant-like profile of action similar to imipramine, a well-known standard antidepressant drug used for comparison, without compromising the animals' motor performance. The putative antidepressant-like action demonstrated here indicates their viability for the development of new therapeutic options for the treatment of depression.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Duarte FS,Andrade Eda S,Vieira RA,Uieara M,Nunes RJ,de Lima TC

doi

10.1016/j.bmc.2006.03.036

subject

Has Abstract

pub_date

2006-08-01 00:00:00

pages

5397-401

issue

15

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00248-3

journal_volume

14

pub_type

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