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Searching for novel N1-substituted benzimidazol-2-ones as non-nucleoside HIV-1 RT inhibitors.

Abstract：

:Non-nucleoside reverse transcriptase inhibitors (NNRTIs) represent an integral part of the currently available combination antiretroviral therapy (cART) contributing to reduce the AIDS-mortality and turned the disease from lethal to chronic. In this context we recently reported a series of 6-chloro-1-(3-methylphenylsulfonyl)-1,3-dihydro-2H-benzimidazol-2-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. In this paper, we describe the design and the synthesis of two novel series of benzimidazolone analogues in which the linker moiety between the phenyl ring and the sulfonyl group was modified and new small lipophilic groups on the benzyl sulfonyl pendant were introduced. All the new obtained compounds were evaluated as RT inhibitors and were also tested against RTs containing single amino acid mutations. Finally, molecular docking studies were performed in order to rationalize the observed activity of the most promising compound.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Ferro S,Buemi MR,De Luca L,Agharbaoui FE,Pannecouque C,Monforte AM

doi

10.1016/j.bmc.2017.05.040

subject

Has Abstract

pub_date

2017-07-15 00:00:00

pages

3861-3870

issue

14

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)30476-5

journal_volume

25

pub_type

杂志文章

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