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The antioxidant role of bile pigments evaluated by chemical tests.

Abstract：

:Bilirubin, biliverdin and their serum albumin complexes were tested as oxyradical scavengers (superoxide generated by the xanthine/xanthine oxidase system and peroxyl radical-trapping antioxidant ability). As superoxide scavengers the free bile pigments showed activities near to that of serum albumin, higher than the water soluble vitamin E analog Trolox and lower than ascorbic acid. The peroxyl radical-trapping antioxidant abilities of the tested bile pigments were much higher than those of the serum albumin and of the same order as their serum albumin complexes. This interaction with peroxyl radicals showed different stoichiometric factors for bilirubin (approximately 2) and biliverdin (approximately 4).

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Farrera JA,Jaumà A,Ribó JM,Peiré MA,Parellada PP,Roques-Choua S,Bienvenue E,Seta P

doi

10.1016/s0968-0896(00)82013-1

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

181-5

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(00)82013-1

journal_volume

2

pub_type

杂志文章

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