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The chemoenzymatic synthesis of neoglycolipids and lipid-linked oligosaccharides using glycosyltransferases.

Abstract：

:The application of glycosyltransferases to the chemoenzymatic synthesis of neoglycosphingolipids and lipid-linked oligosaccharides allows the regio- and stereoselective formation of glycosidic bonds. In our laboratory galactosyl-, sialyl-, and fucosyltransferases have been used to assemble oligosaccharide headgroups directly on a sphingosine derivative without the need for any protection group strategies, including the Lewisx antigen. In complementary studies on N-linked oligosaccharide biosynthesis, chemically phosphorylated dolichol analogues have been tested as substrates for Dol-P-Man synthetase. Also, the substrate recognition of the core beta-1,4-mannosyltransferase from yeast has been investigated using a range of chitobiose derivatives as potential substrates.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Flitsch SL,Goodridge DM,Guilbert B,Revers L,Webberley MC,Wilson IB

doi

10.1016/s0968-0896(00)82075-1

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1243-50

issue

11

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(00)82075-1

journal_volume

2

pub_type

杂志文章

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