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Analysis of the binding specificities of oligomannoside-binding proteins using methylated monosaccharides.

Abstract：

:The binding specificities of the closely related lectins from Canavalia ensiformis and Dioclea grandiflora were examined using specifically O-alkylated mono- and disaccharides. Both lectins accept any substitution at the monosaccharide C2 hydroxyl group. The binding energy of C2-alkylated ligands-concanavalin A complexes increases by 1 kcal mol-1 for the C2-O-ethyl ligand, while the binding energies of the corresponding complexes with the Dioclea lectin are identical. Both lectins accept methyl, but not ethyl, substitution of the C3 hydroxyl, in contrast to earlier reports. The results are interpreted in terms of existing models of the concanavalin A binding site. While the results are consistent with a model of the concanavalin A extended binding site that places the non-reducing terminus of all disaccharides in the monosaccharide binding site, they point to the dangers of interpreting the binding behavior of unnatural saccharide ligands on the basis of crystallographic data obtained with native ligands.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Chervenak MC,Toone EJ

doi

10.1016/s0968-0896(96)00178-2

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

1963-77

issue

11

eissn

0968-0896

issn

1464-3391

pii

S0968089696001782

journal_volume

4

pub_type

杂志文章

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