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Identification of bis-quindolines as new antiinfective agents.

Abstract：

:Several N-substituted quindolines were made to further evaluate the role of N-alkylation on the activity of indoloquinolines as antifungal agents. While N-5 substitution is required for these activities, N-10 alkylation alone leads to inactive products but is tolerated in the presence of N-5 alkyl groups. It was also discovered that bis-quindolines appear to have a more expanded antimicrobial spectrum and lower cytotoxicity than their monomeric counterparts.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Mardenborough LG,Zhu XY,Fan P,Jacob MR,Khan SI,Walker LA,Ablordeppey SY

doi

10.1016/j.bmc.2005.04.008

subject

Has Abstract

pub_date

2005-06-02 00:00:00

pages

3955-63

issue

12

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(05)00290-7

journal_volume

13

pub_type

杂志文章

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