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Design, synthesis, and characterization of peptide nanostructures having ion channel activity.

Abstract：

:We report the synthesis and the functional studies of multiple crown alpha-helical peptides designed to form artificial ion channels. The approach combines the versatility of solid phase peptide synthesis, the conformational predictability of peptidic molecules, and the solution synthesis of crown ethers with engineerable ion-binding abilities. Several biophysical methods were employed to characterize the activity and the mode of action of these crown peptide nanostructures. The 21 residue peptides bearing six 21-EC-7 turned out to facilitate the translocation of ions in a similar fashion to natural ion channels.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Biron E,Otis F,Meillon JC,Robitaille M,Lamothe J,Van Hove P,Cormier ME,Voyer N

doi

10.1016/j.bmc.2003.08.037

subject

Has Abstract

pub_date

2004-03-15 00:00:00

pages

1279-90

issue

6

eissn

0968-0896

issn

1464-3391

pii

S0968089603007673

journal_volume

12

pub_type

杂志文章

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