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Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.

Abstract：

:A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 microg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

de Souza MV,Pais KC,Kaiser CR,Peralta MA,de L Ferreira M,Lourenço MC

doi

10.1016/j.bmc.2009.01.013

subject

Has Abstract

pub_date

2009-02-15 00:00:00

pages

1474-80

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00046-7

journal_volume

17

pub_type

杂志文章

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