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Synthesis and Th1-immunostimulatory activity of α-galactosylceramide analogues bearing a halogen-containing or selenium-containing acyl chain.

Abstract：

:A novel series of CD1d ligand α-galactosylceramides (α-GalCers) were synthesized by incorporation of the heavy atoms Br and Se in the acyl chain backbone of α-galactosyl-N-cerotoylphytosphingosine. The synthetic analogues are potent CD1d ligands and stimulate mouse invariant natural killer T (iNKT) cells to selectively enhance Th1 cytokine production. These synthetic analogues would be efficient X-ray crystallographic probes to disclose precise atomic positions of alkyl carbons and lipid-protein interactions in KRN7000/CD1d complexes.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Hossain MI,Hanashima S,Nomura T,Lethu S,Tsuchikawa H,Murata M,Kusaka H,Kita S,Maenaka K

doi

10.1016/j.bmc.2016.06.007

subject

Has Abstract

pub_date

2016-08-15 00:00:00

pages

3687-95

issue

16

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(16)30429-1

journal_volume

24

pub_type

杂志文章

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