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Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure-anti-mycobacterial activities.

Abstract：

:The preparation of novel 5-aryl-2-thio-1,3,4-oxadiazoles 4a-41 and the computer-aided study of their in vitro anti-tubercular activity against Mycobacterium tuberculosis H37Rv (ATCC 27294) are reported. The average accuracy of the electronic-topological method and neural network methods applied to the activity prediction in leave-one-out cross validation is 80%.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Macaev F,Rusu G,Pogrebnoi S,Gudima A,Stingaci E,Vlad L,Shvets N,Kandemirli F,Dimoglo A,Reynolds R

doi

10.1016/j.bmc.2005.05.011

subject

Has Abstract

pub_date

2005-08-15 00:00:00

pages

4842-50

issue

16

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(05)00404-9

journal_volume

13

pub_type

杂志文章

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