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1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.

Abstract：

:A novel substituted cysteine accessibility method (SCAM) reagent was developed for monoamine uptake transporters. The new reagent, MTS-MPP(+), was a derivative of the neurotoxin and transporter substrate MPP(+). MTS-MPP(+) labeled cysteine residues introduced into the serotonin transporter protein. Although it did not prove to be a substrate, as is MPP(+), it appears to label cysteine residues lining the permeation pore of the transporter more readily than currently available nonspecific SCAM reagents.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Gallardo-Godoy A,Torres-Altoro MI,White KJ,Barker EL,Nichols DE

doi

10.1016/j.bmc.2006.09.058

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

305-11

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00803-0

journal_volume

15

pub_type

杂志文章

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