Abstract：
:Insect neuropeptides are involved in almost all physiological processes in insects, such as diuresis, ecdysis, pheromone biosynthesis and control of muscle activity. Thus, these small peptide hormones and their receptors are promising targets for a novel generation of selective and non-neurotoxic insecticides. However, due to poor bioavailability, pharmacokinetics and short half-life the peptides themselves cannot be used as insect control agents. The past two decades have seen an increase in research into the discovery of non-peptide small molecules that function as mimics for neuropeptides. This review presents an overview on structure-activity studies, conformational analyses and peptidomimetic modifications of selected insect neuropeptides with a special potential for application in pest control.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Scherkenbeck J,Zdobinsky Tdoi
10.1016/j.bmc.2008.12.061subject
Has Abstractpub_date
2009-06-15 00:00:00pages
4071-84issue
12eissn
0968-0896issn
1464-3391pii
S0968-0896(08)01218-2journal_volume
17pub_type
杂志文章,评审abstract：:Synthesis of the 4'-ethynyl and 4'-cyano phosphonates 8-11, which mimic the 5'-monophosphate of 4'-branched 2',3'-didehydro-2',3'-dideoxy nucleosides, was investigated by employing the 3',4'-unsaturated nucleosides (13 and 28) as the starting material. The synthesis was initiated by the electrophilic addition of NIS/(...
journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2012-06-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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更新日期：2010-07-15 00:00:00
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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journal_title：Bioorganic & medicinal chemistry
pub_type： 杂志文章
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更新日期：1999-09-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2005-12-01 00:00:00
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更新日期：2013-04-01 00:00:00
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更新日期：2005-03-01 00:00:00
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journal_title：Bioorganic & medicinal chemistry
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journal_title：Bioorganic & medicinal chemistry
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更新日期：2017-06-15 00:00:00
