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Construction of a chemically and conformationally self-replicating system of amyloid-like fibrils.

Abstract：

:The amyloid-like fibril is considered to be a macromolecular self-assemblage with a highly-ordered quaternary structure, in which numerous beta-stranded polypeptide chains align regularly. Therefore, this kind of fibril has the potential to be engineered into proteinaceous materials, although conformational alteration of proteins from their native form to the amyloid form is a misfolding and undesirable process related to amyloid diseases. In this study, we have attempted to design an artificial system to explore applicability of using the amyloid-like fibril as a construct possessing self-recognition and self-catalytic abilities. A peptide self-replicating system based on the beta-structure of the amyloid-like fibril was designed and constructed. The beta-stranded peptide was self-replicated by the native chemical ligation reaction, and the newly generated peptide was self-assembled into amyloid-like fibrils. Thus, the constructed system was of both chemical and conformational self-replicating fibrils.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Takahashi Y,Mihara H

doi

10.1016/j.bmc.2003.11.022

subject

Has Abstract

pub_date

2004-02-15 00:00:00

pages

693-9

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968089603008083

journal_volume

12

pub_type

杂志文章

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