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1-(1-Arylethylidene)thiosemicarbazide derivatives: a new class of tyrosinase inhibitors.

Abstract：

:A series of 1-(1-arylethylidene)thiosemicarbazide compounds and their analogues were synthesized and characterized by 1H NMR, MS. Their tyrosinase inhibitory activities were investigated by an assay based on the catalyzing ability of tyrosinase for the oxidation of L-DOPA, comparing with 4-methoxycinnamic acid and arbutin. The results showed that (1) all the synthesized compounds could perform a significant inhibitory activity for tyrosinase; (2) for these compounds, the main active moiety interacting with the center of tyrosinase would be thiosemicarbazo group; (3) the inhibitory activity was close related with thiosemicarbazide moieties and the groups attached on the aromatic ring.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Liu J,Yi W,Wan Y,Ma L,Song H

doi

10.1016/j.bmc.2007.10.102

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

1096-102

issue

3

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00961-3

journal_volume

16

pub_type

杂志文章

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