Toward the development of chemoprevention agents (III): synthesis and anti-inflammatory activities of a new class of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes.

Abstract:

:A new series of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes were designed and synthesized. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Sixteen of these new compounds exhibited comparable or better anti-inflammatory activities than aspirin suggesting that they can be further developed as potential anti-inflammatory drug leads. In addition, treatment with these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. Considering their good efficacy and safety profiles, some 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes are worthy to be explored further in assessing the possible link between anti-inflammation and cancer prevention.

journal_name

Bioorg Med Chem

authors

Bi L,Zhao M,Gu K,Wang C,Ju J,Peng S

doi

10.1016/j.bmc.2007.11.017

subject

Has Abstract

pub_date

2008-02-15 00:00:00

pages

1764-74

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(07)00985-6

journal_volume

16

pub_type

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