Abstract:
:A new series of 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes were designed and synthesized. The anti-inflammatory activities of these compounds were tested using the xylene-induced mouse ear edema model. Sixteen of these new compounds exhibited comparable or better anti-inflammatory activities than aspirin suggesting that they can be further developed as potential anti-inflammatory drug leads. In addition, treatment with these anti-inflammatory agents did not prolong tail bleeding time in mice. The structure/activity relationships were also analyzed among these compounds. Considering their good efficacy and safety profiles, some 5-glycylamino-2-substituted-phenyl-1,3-dioxacycloalkanes are worthy to be explored further in assessing the possible link between anti-inflammation and cancer prevention.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Bi L,Zhao M,Gu K,Wang C,Ju J,Peng Sdoi
10.1016/j.bmc.2007.11.017subject
Has Abstractpub_date
2008-02-15 00:00:00pages
1764-74issue
4eissn
0968-0896issn
1464-3391pii
S0968-0896(07)00985-6journal_volume
16pub_type
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