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Tessaric acid derivatives induce G2/M cell cycle arrest in human solid tumor cell lines.

Abstract：

:A series of analogs were synthesized in a straightforward manner from naturally available sesquiterpenes ilicic acid and tessaric acid. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, HBL-100, HeLa, SW1573, T-47D and WiDr. The most potent analog induced considerably growth inhibition in the range 1.9-4.5 microM. Cell cycle studies for tessaric acid derivatives indicated a prominent arrest of the cell cycle at the G(2)/M phase. Damage to the cells was permanent as determine by the so called 24+24 drug schedule.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

León LG,Donadel OJ,Tonn CE,Padrón JM

doi

10.1016/j.bmc.2009.07.053

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

6251-6

issue

17

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00712-3

journal_volume

17

pub_type

杂志文章

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