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A prenylbisabolane with NF-kappaB inhibiting properties from Cascarilla (Croton eluteria).

Abstract：

:Investigation of the bark of Croton eluteria Bennett for biologically active compounds has led to the isolation of the new prenylbisabolane 3, whose structure was assessed by spectroscopic methods. The corresponding known enone 4 and the eudesmane sesquiterpene 2 were also obtained. Compound 3 proved active in selectively inhibiting the induction of NF-kappaB by tumor necrosis factor-alpha in T cells.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Campagnuolo C,Fattorusso E,Petrucci F,Taglialatela-Scafati O,Appendino G,Marquez N,Muñoz E

doi

10.1016/j.bmc.2005.04.025

subject

Has Abstract

pub_date

2005-07-01 00:00:00

pages

4238-42

issue

13

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(05)00324-X

journal_volume

13

pub_type

杂志文章

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