Abstract:
:A series of 1,3-disubstituted 2-iminobenzimidazolines as well as a number of their tautomeric analogs were synthesized. The synthesized compounds were tested for their cytotoxicity against MDCK cells and for inhibiting activity against influenza virus A/California/07/09 (H1N1)pdm09. Based on the results obtained, 50% cytotoxic concentration (CC50), 50% inhibiting concentration (IC50) and selectivity index (SI) were calculated for each compound. It was found that some of synthesized benzimidazole derivatives (7 of 22, 32%) possess strong virus-inhibiting activity against pandemic influenza virus (IC50's in low micromolar range) with quite moderate cytotoxicity (CC50 in the range of thousands micromoles). Due to their high selectivity (highest SI's=50-83) these compounds are of significant interest for further in vivo experiments as well as for further structural optimization and drug development.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Zarubaev VV,Morkovnik AS,Divaeva LN,Karpinskaya LA,Borodkin GSdoi
10.1016/j.bmc.2016.09.036subject
Has Abstractpub_date
2016-11-15 00:00:00pages
5796-5803issue
22eissn
0968-0896issn
1464-3391pii
S0968-0896(16)30726-Xjournal_volume
24pub_type
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