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Synthesis and in vitro evaluation of novel 1,2,4-triazine derivatives as neuroprotective agents.

Abstract：

:The role of novel triazine derivatives against oxidative stress exerted by hydrogen peroxide on differentiated rat pheochromocytoma (PC12) cell line was examined and a consistent protection from H(2)O(2)-induced cell death, associated with a marked reduction in caspase-3 activation, was observed. Moreover, activation of NF-kappaB, a known regulator of a host of genes that involves in specific stress and inflammatory responses by H(2)O(2), was greatly impaired by triazine pretreatment in differentiated PC12 cells. Neuroprotective effect of such compounds may represent a promising approach for treatment of neurodegenerative diseases.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Irannejad H,Amini M,Khodagholi F,Ansari N,Tusi SK,Sharifzadeh M,Shafiee A

doi

10.1016/j.bmc.2010.04.097

subject

Has Abstract

pub_date

2010-06-15 00:00:00

pages

4224-30

issue

12

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00422-0

journal_volume

18

pub_type

杂志文章

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