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Neurotrophic and antileukemic daphnane diterpenoids from Synaptolepis kirkii.

Abstract：

:Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led to the isolation of four new and five known daphnane-type diterpene orthoesters, whose structure was established by spectroscopic data. Full spectroscopic data of the new and known natural products are reported here for the first time. Pronounced neurotrophic and substantial antileukaemia activities of these compounds were found in in vitro assays.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

He W,Cik M,Van Puyvelde L,Van Dun J,Appendino G,Lesage A,Van der Lindin I,Leysen JE,Wouters W,Mathenge SG,Mudida FP,De Kimpe N

doi

10.1016/s0968-0896(02)00163-3

subject

Has Abstract

pub_date

2002-10-01 00:00:00

pages

3245-55

issue

10

eissn

0968-0896

issn

1464-3391

pii

S0968089602001633

journal_volume

10

pub_type

杂志文章

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