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Anti-tumor activity of the farnesyl-protein transferase inhibitors arteminolides, isolated from Artemisa.

Abstract：

:Members of the Artemisia genus are important medicinal plants found throughout the world. Arteminolides A-D (1-4), isolated from the aerial parts of Artemisia, have an inhibitory activity on farnesyl-protein transferase (FPTase; EC 2.5.1.29) in in vitro assay. This study was carried out with the purpose of validating anti-tumor effects of the compounds in human tumor cells and mouse xenograft model. The arteminolides inhibited tumor cell growth in a dose-dependent manner. Furthermore, arteminolide C (3) blocked in vivo growth of human colon and lung tumor xenograft without the loss of body weight in nude mice.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Lee SH,Lee MY,Kang HM,Han DC,Son KH,Yang DC,Sung ND,Lee CW,Kim HM,Kwon BM

doi

10.1016/j.bmc.2003.08.008

subject

Has Abstract

pub_date

2003-10-15 00:00:00

pages

4545-9

issue

21

eissn

0968-0896

issn

1464-3391

pii

S0968089603005546

journal_volume

11

pub_type

杂志文章

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