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1-[2-Hydroxy-3-octadecan-1'-oate]propyl-2'',2'',5'',5''-tetramethyl pyrolidine-N-oxyl-3''-carboxylate as a potential spin probe for membrane structure studies.

Abstract：

:The synthesis of a new minimum steric perturbing proxyl nitroxide, which is a derivative of glycerol and contains a stearic acid moiety, has been carried out. Its localization in model membrane L-alpha-dipalmitoyl phosphatidyl choline (DPPC) was ascertained with the help of ESR, DSC, 1H and 31P NMR techniques. The nitroxide was used for detecting the changes in the phase transition temperature of the model membranes in the presence and absence of drugs. The permeation of the vasodilating drug epinephrine has also been studied using this spin label. The results prove the potential applicability of the new spin probe in the spin labeling of biomembranes.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Katoch R,Trivedi GK,Phadke RS

doi

10.1016/s0968-0896(99)00216-3

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

2753-8

issue

12

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(99)00216-3

journal_volume

7

pub_type

杂志文章

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