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Programmable oligomers targeting 5'-GGGG-3' in the minor groove of DNA and NF-kappaB binding inhibition.

Abstract：

:A series of hairpin oligomers containing benzimidazole (Bi) and imidazopyridine (Ip) rings were synthesized and screened to target 5'-WGGGGW-3', a core sequence in the DNA-binding site of NF-kappaB, a prolific transcription factor important in biology and disease. Five Bi and Ip containing oligomers bound to the 5'-WGGGGW-3' site with high affinity. One of the oligomers (Im-Im-Im-Im-gamma-Py-Bi-Py-Bi-beta-Dp) was able to inhibit DNA binding by the transcription factor NF-kappaB.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Chenoweth DM,Poposki JA,Marques MA,Dervan PB

doi

10.1016/j.bmc.2006.10.051

subject

Has Abstract

pub_date

2007-01-15 00:00:00

pages

759-70

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(06)00883-2

journal_volume

15

pub_type

杂志文章

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