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The design and synthesis of substituted biphenyl libraries.

Abstract：

:A novel scaffold system for the generation of diversity libraries has been designed which allows for rapid modification not only of functional groups, but their spatial arrangements as well. The biphenyl scaffold allows for display of three or four diverse functional groups in a wide variety of spatial arrangements depending on the substitution pattern selected. The libraries are generated by a combination of solution and solid-phase chemistries and are cleaved off the solid-support for screening.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Pavia MR,Cohen MP,Dilley GJ,Dubuc GR,Durgin TL,Forman FW,Hediger ME,Milot G,Powers TS,Sucholeiki I,Zhou S,Hangauer DG

doi

10.1016/0968-0896(96)00060-0

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

659-66

issue

5

eissn

0968-0896

issn

1464-3391

pii

0968-0896(96)00060-0

journal_volume

4

pub_type

杂志文章

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