Abstract:
:Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid) was found to be a potent inhibitor of hemorrhage, with an IC(50) value of 0.035 μM. In addition, most of the antihemorrhagic activity of compounds tested in this experiment showed good correlation to acidity.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Aung HT,Nikai T,Niwa M,Takaya Ydoi
10.1016/j.bmc.2011.10.013subject
Has Abstractpub_date
2011-12-01 00:00:00pages
7000-2issue
23eissn
0968-0896issn
1464-3391pii
S0968-0896(11)00821-2journal_volume
19pub_type
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