Benzenepolycarboxylic acids with potential anti-hemorrhagic properties and structure-activity relationships.

Abstract:

:Previously, we reported the structural requirements of the cinnamic acid relatives for inhibition of snake venom hemorrhagic action. In the present study, we examined the effect of benzenepolycarboxylic acids and substituted benzoic acids against Protobothropsflavoviridis venom-induced hemorrhage. Pyromellitic acid (1,2,4,5-benzenetetracarboxylic acid) was found to be a potent inhibitor of hemorrhage, with an IC(50) value of 0.035 μM. In addition, most of the antihemorrhagic activity of compounds tested in this experiment showed good correlation to acidity.

journal_name

Bioorg Med Chem

authors

Aung HT,Nikai T,Niwa M,Takaya Y

doi

10.1016/j.bmc.2011.10.013

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

7000-2

issue

23

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(11)00821-2

journal_volume

19

pub_type

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