Abstract：
:Parkinson's disease (PD) is a common chronic degenerative disease of the central nervous system. Due to a rapidly aging society worldwide, PD morbidity is on the rise; however, the treatment of PD with conventional drugs carries serious adverse reactions and cannot fix the root cause of PD, the degeneration of dopaminergic neurons, which limits conventional drug usage in clinical practice. In recent years, research on the pathogenesis of PD and its clinical manifestations has led to the discovery of an increasing number of novel targets in PD, including several small molecule targeted compounds. In this paper, we analyze and summarize the most recently published PD literature and review several recently discovered novel targets in PD and their small molecule targeted pharmacologically active agents based on their mechanisms of action and pharmacodynamic profiles.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Zhang H,Tong R,Bai L,Shi J,Ouyang Ldoi
10.1016/j.bmc.2016.02.030subject
Has Abstractpub_date
2016-04-01 00:00:00pages
1419-30issue
7eissn
0968-0896issn
1464-3391pii
S0968-0896(16)30120-1journal_volume
24pub_type
杂志文章,评审abstract：:Green photosynthetic bacteria have unique light-harvesting antenna systems called chlorosomes. Chlorobaculum tepidum, a model organism of the bacteria, biosynthesized monogalactosyl- and rhamnosylgalactosyldiacylglycerides possessing a methylene-bridged palmitoleyl group characterized by a cis-substituted cyclopropane...
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更新日期：2007-06-01 00:00:00
