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D-myo-inositol 1,4,5-trisphosphate analogues as useful tools in biochemical studies of intracellular calcium mobilization.

Abstract：

:Two types of structural variants of D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] were prepared by a chemoenzymatic route. These 6-O-substituted analogues retained the biological activity of Ins(1,4,5)P3, and were able to elicit Ca2+ release from porcine brain microsomes. Moreover, these derivatives allowed the preparation of Ins(1,4,5)P3-based immunogens and affinity matrix which were successfully applied to the preparation and purification of antibodies against Ins(1,4,5)P3. These antibodies displayed discriminative affinity towards Ins(1,4,5)P3, and provide a useful tool to study intracellular Ca2+ mobilization.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Gou DM,Shieh WR,Lu PJ,Chen CS

doi

10.1016/s0968-0896(00)82196-3

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

7-13

issue

1

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(00)82196-3

journal_volume

2

pub_type

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