Synthesis and cytotoxic activity of novel C7-functionalized spongiane diterpenes.

Abstract:

:Based on two lead cytotoxic spongiane diterpenes, a new series of C7-oxygenated derivatives were synthesized and evaluated for their antitumor activity in vitro against the cancer cell lines HeLa and HEp-2. In general, introduction of either hydroxyl or acetoxy groups at C-7 did not improve the resultant cytotoxicity, while the presence of a butyrate ester led to more active compounds (CC(50)=4.0-9.5 microM).

journal_name

Bioorg Med Chem

authors

Arnó M,Betancur-Galvis L,González MA,Sierra J,Zaragozá RJ

doi

10.1016/s0968-0896(03)00230-x

subject

Has Abstract

pub_date

2003-07-17 00:00:00

pages

3171-7

issue

14

eissn

0968-0896

issn

1464-3391

pii

S096808960300230X

journal_volume

11

pub_type

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