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Solution-phase parallel synthesis of substituted chalcones and their antiparasitary activity against Giardia lamblia.

Abstract：

:A library of 25-membered chalcones was prepared by parallel synthesis. Substituted acetophenones and benzaldehydes were condensed using the Claisen-Schmidt base-catalyzed aldol condensation. Several chalcones showed in vitro antiparasitic activity against Giardia lamblia. The highest activity observed for the IC(50) values were 12.72, 15.05 and 15.31 microg/mL, respectively; these are potential leads for the development of antigiardial compounds.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Montes-Avila J,Díaz-Camacho SP,Sicairos-Félix J,Delgado-Vargas F,Rivero IA

doi

10.1016/j.bmc.2009.02.052

subject

Has Abstract

pub_date

2009-09-15 00:00:00

pages

6780-5

issue

18

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(09)00202-8

journal_volume

17

pub_type

杂志文章

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