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omega-(Imidazol-4-yl)alkane-1-sulfonamides: a new series of potent histamine H(3) receptor antagonists.

Abstract：

:omega-(1H-Imidazol-4-yl)alkane-1-sulfonamides were prepared and found to be potent histamine H(3) receptor antagonists. High receptor affinity and a low difference in the data between the bioassays were achieved with 5-(1H-imidazol-4-yl)pentane-1-sulfonic acid 4-chlorobenzylamide (16). Good in vitro profiles were also obtained for 2-hydroxysulfonamide and vinylsulfonamide analogues. This complements and completes the existing set of imidazole-based sulfonamides and sulfamides.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Tozer MJ,Buck IM,Cooke T,Kalindjian SB,Pether MJ,Steel KI

doi

10.1016/s0968-0896(01)00295-4

subject

Has Abstract

pub_date

2002-02-01 00:00:00

pages

425-32

issue

2

eissn

0968-0896

issn

1464-3391

pii

S0968089601002954

journal_volume

10

pub_type

杂志文章

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