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Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses.

Abstract：

:Human polyoma- and papillomaviruses are non-enveloped DNA viruses that cause severe pathologies and mortalities. Under circumstances of immunosuppression, JC polyomavirus causes a fatal demyelinating disease called progressive multifocal leukoencephalopathy (PML) and the BK polyomavirus is the etiological agent of polyomavirus-induced nephropathy and hemorrhagic cystitis. Human papillomavirus type 16, another non-enveloped DNA virus, is associated with the development of cancers in tissues like the uterine cervix and oropharynx. Currently, there are no approved drugs or vaccines to treat or prevent polyomavirus infections. We recently discovered that the small molecule Retro-2(cycl), an inhibitor of host retrograde trafficking, blocked infection by several human and monkey polyomaviruses. Here, we report diversity-oriented syntheses of Retro-2(cycl) and evaluation of the resulting analogs using an assay of human cell infections by JC polyomavirus. We defined structure-activity relationships and also discovered analogs with significantly improved potency as suppressors of human polyoma- and papillomavirus infection in vitro. Our findings represent an advance in the development of drug candidates that can broadly protect humans from non-enveloped DNA viruses and toxins that exploit retrograde trafficking as a means for cell entry.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Carney DW,Nelson CD,Ferris BD,Stevens JP,Lipovsky A,Kazakov T,DiMaio D,Atwood WJ,Sello JK

doi

10.1016/j.bmc.2014.06.053

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

4836-47

issue

17

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(14)00499-4

journal_volume

22

pub_type

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