Abstract:
:Novel ent-kaurane glucosides were synthezised by a Koenigs-Knorr reaction between C17 and C19 alcohols derived from kaurenoic acid and 2,3,4,6-tetra-O-acetyl-glucopyranosyl bromide, followed by the hydrolysis of the acetates. Main products were assayed in vitro and in vivo against blood trypomastigote forms of Trypanosoma cruzi, the aetiological agent of Chagas' disease (American trypanosomiasis). The results allowed to establish structure-activity relationships among these derivatives, as well as pointed out the C19-methylester-C17-O-glucoside as a potential trypanocidal agent, whose trypanocidal profile was shown to be comparable to those of gentian violet and benznidazole.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Batista R,Humberto JL,Chiari E,de Oliveira ABdoi
10.1016/j.bmc.2006.09.048subject
Has Abstractpub_date
2007-01-01 00:00:00pages
381-91issue
1eissn
0968-0896issn
1464-3391pii
S0968-0896(06)00781-4journal_volume
15pub_type
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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更新日期:2005-08-01 00:00:00
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doi:10.1016/j.bmc.2015.06.025
更新日期:2015-08-01 00:00:00
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journal_title:Bioorganic & medicinal chemistry
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doi:10.1016/j.bmc.2015.02.049
更新日期:2015-06-15 00:00:00
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journal_title:Bioorganic & medicinal chemistry
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doi:10.1016/j.bmc.2007.03.081
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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doi:10.1016/j.bmc.2011.05.057
更新日期:2011-07-15 00:00:00
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doi:10.1016/j.bmc.2007.10.094
更新日期:2008-02-15 00:00:00
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journal_title:Bioorganic & medicinal chemistry
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更新日期:2013-09-15 00:00:00
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journal_title:Bioorganic & medicinal chemistry
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journal_title:Bioorganic & medicinal chemistry
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