Abstract：
:Two series of 2-substituted and three new diacetyl benzofurans were synthesized through palladium-catalyzed reactions and their in vitro antimicrobial spectra were assessed. The compounds demonstrated mild to significant growth inhibition against antibiotic-susceptible standard and clinically isolated strains of Gram-positive and Gram-negative bacteria as well as human fungal pathogens. Ampicillin and kanamycin were used as references for antibacterial screening; nystatin and amphotericin B were used for antifungal screening. Varying substitution at the benzofuran moiety and subsequent antimicrobial screening identified the C-3-acetyl functionality as a new structural alternative for optimal antimicrobial property in the benzofuran class of compounds.
journal_name
Bioorg Med Chemjournal_title
Bioorganic & medicinal chemistryauthors
Wahab Khan M,Jahangir Alam M,Rashid MA,Chowdhury Rdoi
10.1016/j.bmc.2005.05.009subject
Has Abstractpub_date
2005-08-15 00:00:00pages
4796-805issue
16eissn
0968-0896issn
1464-3391pii
S0968-0896(05)00419-0journal_volume
13pub_type
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