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Synthesis and anti-influenza virus activity of dihydrofuran-fused perhydrophenanthrenes with a benzyloxy-type side-chain.

Abstract：

:As one of our ongoing research project concerning development of a novel anti-influenza virus agent, dihydrofuran-fused perhydrophenanthrenes were derivatized by means of Williamson ether synthesis and Suzuki-Miyaura cross coupling reactions. Newly synthesized compounds were subjected to evaluation of anti-influenza virus activity using influenza A/Aichi/2/68 (H3N2 subtype) virus strain by a plaque titration method. These investigations revealed that incorporation of benzyl-type ether substituents was effective for exerting the inhibition activity of influenza virus proliferation.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Matsuya Y,Suzuki N,Kobayashi SY,Miyahara T,Ochiai H,Nemoto H

doi

10.1016/j.bmc.2010.01.014

subject

Has Abstract

pub_date

2010-02-15 00:00:00

pages

1477-81

issue

4

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(10)00033-7

journal_volume

18

pub_type

杂志文章

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